GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9815354 | 1 | rs1717027 | chr3:41987920 | ULK4 | chr3:41288091-42003660:- | -1.01 | -11.41 | 1.64E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs1717031 | chr3:41905791 | ULK4 | chr3:41288091-42003660:- | 1 | 11.02 | 1.12E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs1717033 | chr3:41910216 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs2243480 | 1 | rs1723267 | chr7:65473314 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.1E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs1723269 | chr7:65472786 | CCT6P1 | chr7:65216092-65228661:+ | 0.61 | 5.14 | 1.49E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs1723270 | chr7:65469830 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.1E-7 | Diabetic kidney disease |
| THYM | cis | rs9362426 | 1 | rs173334 | chr6:88080223 | C6orf164 | chr6:88032306-88109459:+ | -0.5 | -5.01 | 2.47E-6 | Depressive episodes in bipolar disorder |
| THYM | cis | rs17433780 | 1 | rs17433780 | chr1:89474818 | GBP3 | chr1:89472367-89488549:- | 0.71 | 8.32 | 6.45E-13 | Carotid intima media thickness |
| THYM | cis | rs17459044 | 1 | rs17459044 | chr9:131853624 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.44 | 2.43E-5 | Pelvic organ prolapse (moderate/severe) |
| THYM | cis | rs4237643 | 1 | rs17596617 | chr11:43690717 | HSD17B12 | chr11:43702143-43878160:+ | -0.63 | -7.22 | 1.25E-10 | Forced vital capacity |
| THYM | cis | rs17608059 | 1 | rs17608059 | chr17:13910549 | CDRT15P | chr17:13927815-13928915:+ | -0.5 | -4.95 | 3.18E-6 | Temperament |
| THYM | cis | rs11799420 | 1 | rs17649068 | chr1:171713893 | VAMP4 | chr1:171669298-171711214:- | 0.32 | 4.18 | 6.49E-5 | Hippocampal atrophy |
| THYM | cis | rs11799420 | 1 | rs17649250 | chr1:171720586 | VAMP4 | chr1:171669298-171711214:- | 0.32 | 4.18 | 6.49E-5 | Hippocampal atrophy |
| THYM | cis | rs2275426 | 1 | rs1768803 | chr1:46546208 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs1768816 | chr1:46528599 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.99 | 3.67E-8 | Body mass index |